Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China

Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China

Blog Article

The transmission of Unique Recombinant Forms (URFs) has complicated the molecular epidemic of HIV-1.This increasing genetic diversity has implications for prevention surveillance, diagnosis, and vaccine design.In this study, we characterized the HIV-1 URFs from 135 newly diagnosed HIV-1 infected cases between 2016 and 2020 in Shenyang, northeast China and analyzed the evolutionary relationship ps5 edmonton in stock of them by phylogenetic and recombination approaches.Among 135 URFs, we found that the CRF01_AE/CRF07_BC recombinants were the most common (81.5%, 110/135), followed by CRF01_AE/B (11.

9%, 16/135), B/C (3.7%, 5/135), and others (3.0%, 4/135).94.8% (128/135) of patients infected by URFs were through homosexual contact.

Among 110 URFs_0107, 60 (54.5%) formed 11 subclusters (branch support value = 1) and shared the consistent skeleton yard stakes recombination structure, respectively.Four subclusters have caused small-scale spread among different high-risk populations.Although the recombination structures of URFs_0107 are various, the hotspots of recombinants gathered between position 2,508 and 2,627 (relative to the HXB2 position).Moreover, the CRF07_BC and CRF01AE fragments of URFs_0107 were mainly derived from the MSM population.

In brief, our results reveal the complex recombinant modes and the high transmission risk of URFs_0107, which calls for more attention on the new URFs_0107 monitoring and strict control in the areas led by homosexual transmission route.